Influence of shared epitope-negative HLA-DRB1 alleles on genetic susceptibility to rheumatoid arthritis.

@article{Reviron2001InfluenceOS,
  title={Influence of shared epitope-negative HLA-DRB1 alleles on genetic susceptibility to rheumatoid arthritis.},
  author={Denis Vincent Reviron and Aleth Perdriger and Eric A Toussirot and Daniel Wendling and Nathalie Balandraud and Sandrine Guis and Gilbert Semana and Pierre Tiberghien and Pierre Mercier and Jean Roudier},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 3},
  pages={535-40}
}
OBJECTIVE Most patients with rheumatoid arthritis (RA) express the shared epitope (SE). It is not known whether SE-negative HLA-DRB1 alleles influence the development of RA. This study examined the influence of SE-negative HLA-DR alleles (DRB1*X) on the development of RA in 3 different French populations. METHODS HLA-DRB1 alleles were defined by polymerase chain reaction with sequence-specific oligonucleotide hybridization or sequence-specific primers. SE-negative alleles were classified… CONTINUE READING

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