Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia

@article{Loryan2011InfluenceOS,
  title={Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia},
  author={Irena Loryan and Marja Lindqvist and Inger Johansson and Masahiro Hiratsuka and Ilse van der Heiden and Ron HN van Schaik and Jan G Jakobsson and Magnus Ingelman-Sundberg},
  journal={European Journal of Clinical Pharmacology},
  year={2011},
  volume={68},
  pages={397-406}
}
The basis of high intersubject variability of propofol metabolism is unclear. Therefore, we examined the influence of genetic polymorphisms of the key metabolizing enzymes cytochrome P450 2B6 (CYP2B6) and uridine diphosphate (UDP)-glucuronosyltransferase 1A9 (UGT1A9), age, and sex on propofol biotransformation in vitro and in vivo. Plasma concentrations of propofol, 4-hydroxypropofol, and their glucuronides were measured over 20 min in 105 patients after a single intravenous bolus of propofol… CONTINUE READING

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