Influence of sex and corticotropin-releasing factor pathways as determinants in serotonin sensitivity.

@article{McEuen2009InfluenceOS,
  title={Influence of sex and corticotropin-releasing factor pathways as determinants in serotonin sensitivity.},
  author={Jonathan Gabriel McEuen and Katharine Semsar and Maria A. Lim and Tracy L. Bale},
  journal={Endocrinology},
  year={2009},
  volume={150 8},
  pages={
          3709-16
        }
}
Stress sensitivity and sex are predictive factors in affective disorder susceptibility. Serotonin (5-HT) pathway recruitment by corticotropin-releasing factor (CRF) during stress is necessary in adaptive coping behaviors, but sex differences in such responses have not been investigated. Using selective 5-HT reuptake inhibitor (SSRI) administration to acutely elevate 5-HT in a genetic model of stress sensitivity, we examined behavioral and physiological responses in male and female stress… Expand
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