Influence of sex, estrous cycle, and drug-onset age on cocaine self-administration in rats (Rattus norvegicus).

@article{Kantak2007InfluenceOS,
  title={Influence of sex, estrous cycle, and drug-onset age on cocaine self-administration in rats (Rattus norvegicus).},
  author={Kathleen Kantak and Claudia M Goodrich and Valeria Uribe},
  journal={Experimental and clinical psychopharmacology},
  year={2007},
  volume={15 1},
  pages={37-47}
}
The influence of sex, phase of the estrous cycle, and age of drug onset on cocaine self-administration was examined. Adult male, adult female, and adolescent male rats (Rattus norvegicus) were evaluated using low fixed-ratio (FR) schedules of drug delivery with a single fixed cocaine unit dose or a range of cocaine unit doses with a single FR schedule. Sex differences in adults were observed for mg/kg consumption of the 3.0-mg/kg unit dose, with consumption being significantly less in estrus… CONTINUE READING

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