Influence of serotonin on the immune response.

@article{Jackson1985InfluenceOS,
  title={Influence of serotonin on the immune response.},
  author={J Craig Jackson and Ren{\'e} Cross and Richard N. Walker and William R. Markesbery and William H. Brooks and Thomas L. Roszman},
  journal={Immunology},
  year={1985},
  volume={54 3},
  pages={505-12}
}
The present study investigates the influence of pharmacological agents known to regulate biosynthesis of the neurotransmitter, serotonin (5-hydroxytryptamine, 5-HT) on the primary antibody response to sheep red blood cells (SRBC) in the CBA mouse. Systemic administration of 5-HT (4-100 mg/kg) or its precursor, 5-hydroxytryptophan (5-HTP, 50-400 mg/kg), 30-60 min before immunization resulted in dose-dependent suppression of both the IgM and IgG plaque-forming cell (PFC) response to SRBC… CONTINUE READING

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