Influence of senna, fibre, and fibre + senna on colonic transit in loperamide-induced constipation.

@article{Ewe1993InfluenceOS,
  title={Influence of senna, fibre, and fibre + senna on colonic transit in loperamide-induced constipation.},
  author={Klaus Ewe and B. Ueberschaer and Andreas G. Press},
  journal={Pharmacology},
  year={1993},
  volume={47 Suppl 1},
  pages={242-8}
}
Retarded colonic transit and disturbed defecation are the most prominent pathophysiological mechanisms in constipation. Both may be influenced by bulking agents and by laxatives such as senna. Direct measurements of the influence of such substances on colonic transit are rare mainly because of technical problems. We measured gastric emptying, small and large intestinal transit in 24 healthy volunteers by a newly developed method employing a metal detector. Twelve persons taking a normal diet… CONTINUE READING