Influence of selenium on 3-methylcholanthrene induced skin carcinogenesis in mice.

@article{Bansal1988InfluenceOS,
  title={Influence of selenium on 3-methylcholanthrene induced skin carcinogenesis in mice.},
  author={Mohinder Pal Bansal and Gautam Sen Gupta},
  journal={Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer},
  year={1988},
  volume={8 7 Spec No},
  pages={49-53}
}
Incidence of skin papillomas/tumors have been studied in ICRC male mice after surface application of 3-methylcholanthrene (MCA) after selenium treatment. Decrease in percentage incidence and tumor burden was noticed. Also increase in latent period of induction was observed. As no influence of selenium was noticed on arylhydrocarbon-hydroxylase activity in skin and liver, so activation/inactivation of carcinogen is ruled out with selenium treatment. Since there is significant increase in… CONTINUE READING