Influence of selenium (antioxidant) on gliclazide induced hypoglycaemia/anti hyperglycaemia in normal/alloxan-induced diabetic rats

@article{Satyanarayana2006InfluenceOS,
  title={Influence of selenium (antioxidant) on gliclazide induced hypoglycaemia/anti hyperglycaemia in normal/alloxan-induced diabetic rats},
  author={Srinath Satyanarayana and J. Rajad Sekhar and K. Eswar Kumar and L. Bacchus Shannika and Bettaiya Rajanna and Sharada Rajanna},
  journal={Molecular and Cellular Biochemistry},
  year={2006},
  volume={283},
  pages={123-127}
}
Oxidative stress is involved in diabetes mellitus and its complications. Since diabetes is a stress-related disorder, supplementation with antioxidants may improve the condition. The purpose of this study is to know the effect of oral administration of selenium on blood glucose and its influence on gliclazide induced hypoglycaemia/antihyperglycaemia in normal and alloxan-induced diabetic rats. Albino rats of either sex were divided into three groups of six each. Group-I/II/III were treated with… Expand
Effect of α-lipoic acid on gliclazide-induced hypoglycemia/antihyperglycemia in normal/alloxan-induced diabetic rats
TLDR
Examination of the effect of oral administration of α-lipoic acid on blood glucose and its potential influence on gliclazide-induced hypoglycemia in normal and diabetic rats found it to have a positive influence on the hypoglycemic activity of glic lazide. Expand
Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats
Introduction: Diabetes is a metabolic disorder of several etiologies, many oral anti-hyperglycemic agents such as sulfonylurea, biguanides are obtainable, but these agents have side effects, thusExpand
A high-selenium diet induces insulin resistance in gestating rats and their offspring.
TLDR
Supranutrition of Se as a Se-enriched yeast in rats induced gestational diabetes and insulin resistance and expression of six selenoprotein genes, in particular Gpx1, was linked to this metabolic disorder. Expand
Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant
TLDR
The antioxidant role of nutritional supplementation of selenium in the management of major chronic metabolic disorders, including hyperlipidaemia, hyperglycaemia, and hyperphenylalaninemia is reviewed. Expand
Intake of vitamin E and other antioxidant nutrients in early life and the development of advanced ?-cell autoimmunity and clinical type 1 diabetes
TLDR
Analysis of epidemiological analyses of the associations of vitamin e and other antioxidant nutrients with the development of type 1 diabetes and the sociodemographic and lifestyle determinants of intake of antioxidant nutrients and consumption of their dietary sources among finnish pregnant women concluded that maternal antioxidant intake during pregnancy and the consumption of the dietary sources during pregnancy is associated with pre-type 1 diabetes in the child. Expand
Micronutrient status in type 2 diabetes: a review.
TLDR
Evidence of changes in trace mineral and vitamin metabolism as a consequence of type 2 diabetes is reviewed and the optimal level of micronutrient supplementation to achieve glucose homeostasis in type 2 diabetics remains a challenge. Expand
Effects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes
TLDR
The efficacy of selenium supplementation in preventing new-onset type 2 diabetes in the NPC (Nutritional Prevention of Cancer) trial was examined, a randomized, double-blind, placebo-controlled study of 1312 participants who were recruited in 1983 to 1991 from 7 dermatology clinics in areas of low Selenium consumption of the eastern United States. Expand
Serum Selenium Status in Patients with Type 2 Diabetes and Control Group
TLDR
Serum levels of selenium in diabetic patients with significant difference statistically were lower than the control group, and prospective studies along with selenum supplementation and investigating its effect on incidence of diabetes are accordingly needed. Expand
Synthesis, characterization and antidiabetic properties of N(1)-2,4-dihydroxybenzylidene-N(4)-2-hydroxybenzylidene-S-methyl-thiosemicarbazidato-oxovanadium(IV).
TLDR
It was concluded that VOL can regenerate B cells of the Pancreas in experimental diabetes and has an antidiabetic and protective effects on the pancreas. Expand
Minerals and Diabetes Mellitus
TLDR
The results obtained from the studies show that mineral supplementation in the prevention or management of diabetes cannot provide sufficient evidence and there is need for evidence supported by studies that require larger sample size and longer follow-up. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 31 REFERENCES
Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats
TLDR
Supplementation of antioxidants like L-ascorbic acid was found to improve tolbutamide response in normal and diabetic rats. Expand
[Effects of selenium on the serum glucose and insulin levels in diabetic rats].
TLDR
The data present the new finding that Se reduced the high level of serum glucose in diabetic rats and insulin release from isolated pancreatic islets was dose-dependently accelerated by the addition of selenite. Expand
Selenium in diabetes: Effects of selenium on nephropathy in type I streptozotocin‐induced diabetic rats
Oxidative stress is involved in diabetes mellitus and its complications. Selenium is a nutritional antioxidant, especially because it is required for the activity of selenium-dependent glutathioneExpand
New experimental observation on the relationship of selenium and diabetes mellitus
TLDR
Although oral administration of a high dose of selenite orally administered to the alloxan-induced diabetic Kun-Ming mice for 4 wk failed to reduce hyperglycemia, selenites treatment still maintained the antioxidant beneficial effect on the diabetic mice. Expand
A novel effect of selenium on streptozotocin-induced diabetic mice.
TLDR
The results show insulin-like in vivo action of selenium in diabetic mice, and selenite treatment of diabetic mice restored these parameters to near control values. Expand
Hemobiological properties of gliclazide.
TLDR
Gliclazide restores low plasminogen activity to normal in NIDDM patients previously treated with first-generation sulfonyl-ureas and increases fibrinolytic potential by increasing endothelial cell tissue plAsminogen activator and pre-kallikrein activity. Expand
Insulinlike Effects of Sodium Selenate in Streptozocin-Induced Diabetic Rats
TLDR
Sodium selenate appears to have insulinlike effects when administered in vivo in response to streptozocin-induced diabetic rats, and enhanced weight gain in responding diabetic rats to that seen in controls. Expand
Influence of gliclazide on glucose-stimulated insulin release in man.
TLDR
The influence of the SU gliclazide on glucose-stimulated insulin release in eight healthy male volunteers was assessed and no difference was observed in plasma C-peptide response at the end of the 32-mmol/L hyperglycemic glucose clamps. Expand
Effect of a sulfonylurea (gliclazide) treatment on insulin sensitivity and glucose-mediated glucose disposal in patients with non-insulin-dependent diabetes mellitus (NIDDM).
Five male non-obese newly diagnosed NIDDM and 5 age-, sex- and body mass index (BMI) matched healthy controls without a family history of diabetes were submitted to a frequently sampled intravenousExpand
Free Radical Activity in Type 2 Diabetes
TLDR
A reduction in superoxide dismutase and the imbalance in the redox status of the plasma and lysate thiol demonstrated is consistent with an increase in free radical activity in Type 2 diabetes. Expand
...
1
2
3
4
...