Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis

@inproceedings{Wu2014InfluenceOS,
  title={Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis},
  author={Yu-Chang Bryan Wu and Louisa K. James and Jason A Vander Heiden and Mohamed Uduman and Stephen R. Durham and Steven H. Kleinstein and David Kipling and Hannah J Gould},
  booktitle={The Journal of allergy and clinical immunology},
  year={2014}
}
BACKGROUND Previous studies of immunoglobulin gene sequences in patients with allergic diseases using low-throughput Sanger sequencing have limited the analytic depth for characterization of IgE repertoires. OBJECTIVES We used a high-throughput, next-generation sequencing approach to characterize immunoglobulin heavy-chain gene (IGH) repertoires in patients with seasonal allergic rhinitis (AR) with the aim of better understanding the underlying disease mechanisms. METHODS IGH sequences in… CONTINUE READING