Influence of respiratory syncytial virus strain differences on pathogenesis and immunity.

  title={Influence of respiratory syncytial virus strain differences on pathogenesis and immunity.},
  author={Jos{\'e} A Melero and Martin L Moore},
  journal={Current topics in microbiology and immunology},
Molecular epidemiology studies have provided convincing evidence of antigenic and sequence variability among respiratory syncytial virus (RSV) isolates. Circulating viruses have been classified into two antigenic groups (A and B) that correlate with well-delineated genetic groups. Most sequence and antigenic differences (both inter- and intra-groups) accumulate in two hypervariable segments of the G-protein gene. Sequences of the G gene have been used for phylogenetic analyses. These studies… CONTINUE READING
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