Influence of residue 44 on the activity of the M2 proton channel of influenza A virus.

@article{Betkov2005InfluenceOR,
  title={Influence of residue 44 on the activity of the M2 proton channel of influenza A virus.},
  author={Tatiana Bet{\'a}kov{\'a} and Fedor {\vC}iampor and Alan J. Hay},
  journal={The Journal of general virology},
  year={2005},
  volume={86 Pt 1},
  pages={181-4}
}
The influenza A virus M2 proton channel plays a role in two stages of virus replication. The proteins of two closely related strains of the avian H7 subtype of influenza A virus, Rostock and Weybridge, were found to differ in their pH-modulating activities and activation characteristics. Of three amino acid differences at residues 27, 38 and 44 within the membrane-spanning domain, substitution at residue 44 was necessary and sufficient to account for differences in trans-Golgi pH-modulating… CONTINUE READING