Influence of renal failure on the pharmacokinetics and neuromuscular effects of a single dose of rapacuronium bromide.

@article{Szenohradszky1999InfluenceOR,
  title={Influence of renal failure on the pharmacokinetics and neuromuscular effects of a single dose of rapacuronium bromide.},
  author={Janos Szenohradszky and James E. Caldwell and Peter M C Wright and Rachel Clare Brown and Michael Lau and Andrew M Luks and Dennis M. Fisher},
  journal={Anesthesiology},
  year={1999},
  volume={90 1},
  pages={24-35}
}
BACKGROUND Because renal function affects the elimination of muscle relaxants, each new muscle relaxant must be evaluated in patients with renal failure. Accordingly, the neuromuscular effects and pharmacokinetics of rapacuronium were identified in patients with renal failure. METHODS Rapacuronium (1.5 mg/kg) was administered to 10 healthy volunteers and 10 patients with renal failure who were undergoing non-transplant surgery, were 18-45 yr old, and were anesthetized with propofol. The… CONTINUE READING