Influence of receptor number on the stimulation by salmeterol of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor.

@article{McDonnell1998InfluenceOR,
  title={Influence of receptor number on the stimulation by salmeterol of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor.},
  author={J McDonnell and Muhammad Liaque Latif and E. I. S. Rees and Nicola J. Bevan and Stephen J Hill},
  journal={British journal of pharmacology},
  year={1998},
  volume={125 4},
  pages={
          717-26
        }
}
1. The beta2-agonist salmeterol is a potent relaxant of airway smooth muscle with a long duration of action. Previous studies of cyclic AMP accumulation, however, have indicated that salmeterol is a low efficacy beta2-agonist when compared to isoprenaline. Here we have compared the properties of salmeterol and isoprenaline as stimulants of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor to different levels (50 and 310 fmol mg protein(-1)). 2. Gene transcription… CONTINUE READING

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