Influence of rabeprazole and lansoprazole on the pharmacokinetics of tacrolimus in relation to CYP2C19, CYP3A5 and MDR1 polymorphisms in renal transplant recipients.

@article{Miura2007InfluenceOR,
  title={Influence of rabeprazole and lansoprazole on the pharmacokinetics of tacrolimus in relation to CYP2C19, CYP3A5 and MDR1 polymorphisms in renal transplant recipients.},
  author={Masatomo Miura and Kazuyuki Inoue and Hideaki Kagaya and Shigeru Satoh and Hitoshi Tada and Yoshinori Sagae and Tomonori Habuchi and Toshio Suzuki},
  journal={Biopharmaceutics & drug disposition},
  year={2007},
  volume={28 4},
  pages={167-75}
}
The objective of this study was to evaluate whether genetic polymorphisms of CYP2C19, CYP3A5 and MDR1 significantly impact the interaction between tacrolimus and rabeprazole or lansoprazole. Seventy-three recipients were randomly assigned after renal transplantation to receive repeated doses of tacrolimus for 28 days with a regimen of either 20 mg of rabeprazole or 30 mg of lansoprazole. Blood concentrations of tacrolimus were measured by microparticle enzyme immunoassay. The mean daily dose… CONTINUE READING
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