Influence of quercetin on the pharmacokinetics of ranolazine in rats and in vitro models

  title={Influence of quercetin on the pharmacokinetics of ranolazine in rats and in vitro models},
  author={Potti Ravindra Babu and Katipudi N. Babu and P L Haroled Peter and Kowti Rajesh and P. Jawahar Babu},
  journal={Drug Development and Industrial Pharmacy},
  pages={873 - 879}
  • P. Babu, K. N. Babu, P. Babu
  • Published 30 April 2013
  • Biology, Chemistry
  • Drug Development and Industrial Pharmacy
The aim of our study was to enhance the bioavailability of ranolazine by using herbal-bioenhancer quercetin in rats and to study the role of P-glycoprotein (P-gp) in vitro models. In single dose study (SDS), rats were divided into four groups, Group I was treated with 0.5% sodium carboxy methyl cellulose (SCMC), Group II was treated with ranolazine (14 mg/kg), Group III was treated with quercetin (20 mg/kg) and Group IV was treated with both ranolazine and quercetin. The blood samples were… 
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