Influence of processing parameters and formulation factors on the drug release from tablets powder-coated with Eudragit L 100-55.

@article{Sauer2007InfluenceOP,
  title={Influence of processing parameters and formulation factors on the drug release from tablets powder-coated with Eudragit L 100-55.},
  author={Dorothea Sauer and Weijia C Zheng and Lonique B Coots and James W. McGinity},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2007},
  volume={67 2},
  pages={464-75}
}
The aim of this study was to develop a dry powder coating process for chlorpheniramine maleate (CPM) tablets using Eudragit L 100-55 as the delayed release polymer. Powder coating, a water and organic solvent-free process, was investigated as a method to prevent the migration of an ionizable, highly water soluble model drug into the polymeric film during the coating process. Eudragit L 100-55 was pre-plasticized with triethyl citrate (TEC) using hot-melt extrusion at levels of 20%, 30%, and 40… CONTINUE READING

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