Influence of probenecid on serum levels and urinary excretion of cinoxacin.

@article{Rodrguez1979InfluenceOP,
  title={Influence of probenecid on serum levels and urinary excretion of cinoxacin.},
  author={Nicolau Rodr{\'i}guez and Paul O. Madsen and Peter G. Welling},
  journal={Antimicrobial agents and chemotherapy},
  year={1979},
  volume={15 3},
  pages={
          465-9
        }
}
Serum levels and urinary excretion of cinoxacin were examined in healthy individuals after a two-step intravenous infusion in the presence and absence of probenecid. After dosing cinoxacin alone, steady-state serum levels were approached in 1 h and were maintained for an additional 2 h with a reduced infusion rate. After probenecid pretreatment, serum levels of cinoxacin continued to increase during 3 h of infusion, reaching levels approximately double those obtained with cinoxacin alone. The… CONTINUE READING