Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1α pathway in patients with hepatocellular carcinoma

@article{Xu2014InfluenceOP,
  title={Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1α pathway in patients with hepatocellular carcinoma},
  author={Weiguang Xu and Jung-Hee Kwon and Young Ho Moon and Y. B. Kim and Yun Suk Yu and Namgyu Lee and Kwan Yong Choi and Yun Kim and Yong Keun Park and Bong Wan Kim and Hee Jung Wang},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2014},
  volume={140},
  pages={1507-1515}
}
AbstractPurpose Although transcatheter arterial chemoembolization (TACE) is the most common treatment option in patients with hepatocellular carcinoma (HCC), its clinical benefits remain still controversial. Since TACE induces hypoxic necrosis in tumors, hypoxia-inducible factor 1α (HIF-1α) could critically affect biology in residual tumors after TACE treatment and subsequent prognosis. However, HIF-1α and its prognostic relevance in TACE have rarely been examined in human specimens. In the… CONTINUE READING
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The Changes of HIF-1α and VEGF Expression After TACE in Patients With Hepatocellular Carcinoma.

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