Corpus ID: 10862197

Influence of pregnancy on the pharmacokinetic disposition of two aromatic retinoids (etretinate and acitretin) in the rat. II. Single and multiple oral dosing studies.

@article{Brouwer1989InfluenceOP,
  title={Influence of pregnancy on the pharmacokinetic disposition of two aromatic retinoids (etretinate and acitretin) in the rat. II. Single and multiple oral dosing studies.},
  author={K. Brouwer and P. McNamara},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1989},
  volume={17 6},
  pages={
          652-5
        }
}
  • K. Brouwer, P. McNamara
  • Published 1989
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
  • During a multiple dose regimen of etretinate, steady state trough plasma concentrations of etretinate in nonpregnant female rats reached their peak levels (15 ng/ml) by day 10 and remained between 10 and 15 ng/ml through day 19. Steady state trough concentrations of acitretin in nonpregnant animals following etretinate multiple dosing reached their peak levels (53 ng/ml) at day 7 and declined to 16 ng/ml at day 19. A similar decline was observed following multiple oral dosing of acitretin… CONTINUE READING
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