Influence of posture on hepatic perfusion and the presystemic biotransformation of propranolol: simulation of the food effect.

@article{Modi1988InfluenceOP,
  title={Influence of posture on hepatic perfusion and the presystemic biotransformation of propranolol: simulation of the food effect.},
  author={Marlene W Modi and James M. Hassett and David Lalka},
  journal={Clinical pharmacology and therapeutics},
  year={1988},
  volume={44 3},
  pages={268-74}
}
Several research groups have reported that the oral administration of propranolol with protein-rich food leads to a marked increase (mean + 60%) in the area under the drug plasma concentration-time curve (AUC oral) of this highly metabolized and well-absorbed drug. It has been postulated that this "food effect" is caused at least in part by a transient… CONTINUE READING