Influence of positive end-expiratory pressure on left ventricular performance.

  title={Influence of positive end-expiratory pressure on left ventricular performance.},
  author={François Jardin and J. C. Farcot and L. Boisante and Nicolas Curien and A. Margairaz and J. P. Bourdarias},
  journal={The New England journal of medicine},
  volume={304 7},
Although left ventricular dysfunction is common during ventilatory support with positive end-expiratory pressure (PEEP), the mechanism of this disorder remains unclear. In 10 patients with the adult respiratory-distress syndrome we studied the effects of a stepwise increase in PEEP from 30 cm H2O on left ventricular output, intracardiac transmural pressures, and two-dimensional echocardiographic measurements of left ventricular cross-sectional area at end-systole and at end-diastole… CONTINUE READING