Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency.

@article{Laczmanska2006InfluenceOP,
  title={Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency.},
  author={Izabela Laczmanska and Justyna Gil and Pawel Karpinski and Agnieszka Stembalska and Joanna Kozlowska and Halina Busza and Alicja Trusewicz and Karolina A. Pesz and David Ramsey and Kamila Schlade-Bartusiak and Nikolaus Blin and Maria Malgorzata Sasiadek},
  journal={Environmental and molecular mutagenesis},
  year={2006},
  volume={47 9},
  pages={
          666-73
        }
}
Analysis of the combined effects of polymorphisms in genes encoding xenobiotic metabolizing enzymes (XMEs) and DNA repair proteins may be a key to understanding the role of these genes in the susceptibility of individuals to mutagens. In the present study, we performed an in vitro experiment on lymphocytes from 118 healthy donors that measured the frequency of diepoxybutane (DEB) induced sister chromatid exchanges (SCEs) in relation to genetic polymorphisms in genes coding for XMEs (CYP1A1… CONTINUE READING

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