Influence of pleural pressure variations on cardiovascular system dynamics: a model study

@article{Goldstein2006InfluenceOP,
  title={Influence of pleural pressure variations on cardiovascular system dynamics: a model study},
  author={Yaakov Goldstein and Rafael Beyar and Samuel Sideman},
  journal={Medical and Biological Engineering and Computing},
  year={2006},
  volume={26},
  pages={251-259}
}
A mathematical model of the human cardiovascular system (CVS) is used to study the effect of different respiratory manoeuvres on the circulation. The model simulates the normal CVS and the interaction between the heart and the intrathoracic pressure. The vascular system is represented by resistive, capacitive and inertial elements whereas the ventricles are assumed to function according to the time-varying elastance concept based on their transmural pressures. The model predicts that normal… 
Age-dependent cardiopulmonary interaction during airway obstruction: a simulation model.
  • E. Goldman
  • Medicine
    American journal of physiology. Heart and circulatory physiology
  • 2010
TLDR
Simulation of inspiratory loading in young and older subjects with a mathematical model that simulated beat-by-beat fluctuations in cardiopulmonary variables identified a linear increase of left ventricular transmural pressures with negative intrathoracic pressure that was nearly 38% larger than that in the younger group.
The role of the autonomic nervous system in hypertension: a bond graph model study.
TLDR
The model agrees with human physiological and pathological features in hemodynamic parameters and carotid baroreflex function curves, and indicates the role of ANS in blood pressure regulation and heart protection and may provide a valid approach to study the pathophysiological conditions of the cardiovascular system and the mechanism of AnS regulation.
Using a human cardiovascular-respiratory model to characterize cardiac tamponade and pulsus paradoxus
TLDR
The modeling study of cardiac tamponade dissects the roles played by septal motion, atrioventricular and right-left ventricular interactions, pulmonary blood pooling, and the depth of respiration and finds that simulating active sePTal contraction is important in modeling ventricular interaction.
Simulating Cardiovascular Haemodynamics by Bond Graph Technique
TLDR
A bond graph model for simulating cardiovascular haemodynamics could simulate the performance the cardiovascular system validly and the results are consistent with the pathological features.
Clinical Applications of a Human Cardiovascular-Respiratory System Model: Studying Ventricular Mechanics in Disease and Treatment
TLDR
A large-scale model of the human cardiovascular-respiratory system (H-CRS) that integrates heart mechanics, hemodynamics, circulatory and gas transport aspects of the lung, brain and whole body tissue, and nervous system ii control of the cardiovascular and respiratory systems into a single model that can be used to analyze the dynamic behavior of the normal and deranged cardiopulmonary system.
Computer modelling and wave intensity analysis of perinatal cardiovascular function and dysfunction
TLDR
Computer models of the entire circulation for the normal fetus and neonate are described, derived from a model of the adult circulation that also provides an essential haemodynamic reference point, to enable investigation of a wide range of circulatory interactions in the perinatal period.
On the Design, Modeling, and Control of a Hybrid Pump System for Dynamic Pressurization of Explanted Mammalian Hearts
DUGAN, SEAN PATRICK-MICHAEL. On the Design, Modeling, and Control of a Hybrid Pump System for Dynamic Pressurization of Explanted Mammalian Hearts. (Under the direction of Dr. Gregory D. Buckner.) A
A chest drainage system with a real-time pressure monitoring device.
TLDR
This real-time pleural pressure monitoring device can help clinicians objectively judge the extent of recovery of the chest condition and can be used as an effective adjunct with the current chest drain system.

References

SHOWING 1-10 OF 62 REFERENCES
A re‐evaluation of the hemodynamic consequences of intermittent positive pressure ventilation
TLDR
This work has found that the “reverse pulsus paradoxus” during inspiration reflects both transmission of the increased intrathoracic pressure to the thoracic aorta and an increase in LV stroke volume (SV).
Effect of negative pleural pressure on left ventricular hemodynamics.
Dlastolic Pressure‐Volume Relationship in the Canine Left Ventricle
TLDR
It was concluded that the a constant was primarily affected by changes in left ventricular wall stiffness, and the contribution of changes in wall stiffness may be quantified.
Acute Hemodynamic Interventions Shift the Diastolic Pressure‐Volume Curve in Man
TLDR
Frame-by-frame analysis of angiograms in 16 patients revealed that hemodynamic interventions are capable of producing substantial shifts in the diastolic pressure-volume curve, and called into question the use of end-diastolicpressure interchangeably with end-iastolic fiber length when interpreting systolic events in terms of the Frank-Starling mechanism.
Mechanical effects of inspiration on heart functions: a review.
TLDR
Left ventricular stroke volume can still decrease without a decrease in left ventricular filling and even when increases in venous return have been prevented, indicating the fall in stroke volume during inspiratory effort appears to be caused by a variety of factors.
Left ventricular hemodynamics during respiration.
TLDR
Increases in both RHV and effective LV afterload are created by the inspiratory fall in Ppl and summate to decrease LVSV.
Effects of respiration on cardiac performance.
TLDR
In anesthetized dogs, an increase in left ventricular filling pressure (LVFP) with both constant and increasing lung volume during an inspiratory effort is found consistent with the hypothesis that a fall in pleural pressure afterloads the left ventricle.
Lung volume and pleural pressure effects on ventricular function.
TLDR
The data indicate that the apparent alteration of ventricular function that occurs during continuous positive-pressure ventilation is produced by the associated increase in lung volume and that a right ventricular afterload-ventricular interdependence effect is not the responsible mechanism.
...
1
2
3
4
5
...