Influence of plasma and inflammatory proteins on the ultrastructure of exogenous surfactant.

  title={Influence of plasma and inflammatory proteins on the ultrastructure of exogenous surfactant.},
  author={Andreas Schmiedl and Norbert Krug and Jens M. Hohlfeld},
  journal={Journal of electron microscopy},
  volume={53 4},
We tested the hypothesis that albumin, fibrinogen and eosinophilic cationic protein (ECP) alter not only the function but also the ultrastructural composition of natural bovine surfactant (Alveofact). Therefore, natural bovine surfactant was mixed with equimolar concentrations of these proteins for 2 h and prepared for electron microscopical examination. Volume fractions, the volume to surface ratio and the volume-weighted mean volume were determined by using various stereological methods… Expand
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