Influence of placentally mediated fetal growth restriction on the onset of puberty in male and female lambs.

  title={Influence of placentally mediated fetal growth restriction on the onset of puberty in male and female lambs.},
  author={P Da Silva and R. P. Aitken and Stewart M. Rhind and Paul A. Racey and Jacqueline M. Wallace},
  volume={122 3},
The onset of puberty in prenatally growth-restricted versus normally grown lambs of both sexes, born in April and housed under natural photoperiod, was examined. Singleton pregnancies were established and adolescent ewes were offered a high or moderate nutrient intake throughout gestation. Placental mass was reduced (P < 0.001) in high compared with moderate intake dams and resulted in the birth of growth-restricted and normal birth weight offspring, respectively. At birth, female lambs weighed… 

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The data suggest that in rapidly growing adolescent ewes, the established anabolic drive to maternal tissue synthesis is maintained at the expense of the gradually evolving nutrient requirements of the gravid uterus, resulting in a major restriction in placental growth and a highly significant decrease in birthweight.

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