Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

@article{Shoba1998InfluenceOP,
  title={Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.},
  author={G. Shoba and Dike-Ndudim Joy and Tshidibi Dipa Joseph and Muhammed Majeed and R Samuel Rajendran and Pradeep Srinivas},
  journal={Planta medica},
  year={1998},
  volume={64 4},
  pages={
          353-6
        }
}
The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. [] Key Method In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4…

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