Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

  title={Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.},
  author={G. Shoba and D. Joy and T. Joseph and M. Majeed and R. Rajendran and P. S. Srinivas},
  journal={Planta medica},
  volume={64 4},
  • G. Shoba, D. Joy, +3 authors P. S. Srinivas
  • Published 1998
  • Medicine
  • Planta medica
  • The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. [...] Key Method In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4…Expand Abstract

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