• DOI:10.1055/S-2006-957450
Corpus ID: 16731342

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

@article{Shoba1998InfluenceOP,
  title={Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.},
  author={G. Shoba and D. Joy and T. Joseph and M. Majeed and R. Rajendran and P. S. Srinivas},
  journal={Planta medica},
  year={1998},
  volume={64 4},
  pages={
          353-6
        }
}

G. Shoba, D. Joy, +3 authors P. S. Srinivas

Published 1998

Medicine

Planta medica

The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. [...] Key Method In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4…Expand Abstract

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