Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
@article{Shoba1998InfluenceOP, title={Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.}, author={G. Shoba and D. Joy and T. Joseph and M. Majeed and R. Rajendran and P. S. Srinivas}, journal={Planta medica}, year={1998}, volume={64 4}, pages={ 353-6 } }
The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. [...] Key Method In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4…Expand Abstract
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