Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

@article{Shoba1998InfluenceOP,
  title={Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.},
  author={G. Shoba and D. Joy and T. Joseph and M. Majeed and R. Rajendran and P. S. Srinivas},
  journal={Planta medica},
  year={1998},
  volume={64 4},
  pages={
          353-6
        }
}
  • G. Shoba, D. Joy, +3 authors P. S. Srinivas
  • Published 1998
  • Medicine
  • Planta medica
  • The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. [...] Key Method In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4…Expand Abstract

    Figures, Tables, and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Effects of Piperine on the Intestinal Permeability and Pharmacokinetics of Linarin in Rats
    10
    Selective reduction in the expression of UGTs and SULTs, a novel mechanism by which piperine enhances the bioavailability of curcumin in rat
    15

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 19 REFERENCES
    1981)lndian Drugs 19,31
    • 1981
    1993)J. chromatography 259,367—369
    • 1978
    AIDS Treatment News
    • 1993
    AIDS Treatment News 176,1—3
    • 1993
    Acta Pharmacol. Toxxicol
    • 1978
    Development of Unuani drugs from herbal sources and the role of elements in their mechanism of action
    • 1985
    Eur. J. Clin. Pharmacol
    • 1991
    Handbook of Medicinal Plants, Vol. 1, central Council for Research in Indian Medicine and Homeopathy
    • 1977
    Indian Drugs 19
    • 1981
    J. Chromatography
    • 1993