Influence of physiologic hyperglucagonemia on basal and insulin-inhibited splanchnic glucose output in normal man.

@article{Felig1976InfluenceOP,
  title={Influence of physiologic hyperglucagonemia on basal and insulin-inhibited splanchnic glucose output in normal man.},
  author={Philip F. Felig and John Wahren and Rosa E. Hendler},
  journal={The Journal of clinical investigation},
  year={1976},
  volume={58 3},
  pages={
          761-5
        }
}
To evaluate the effects of physiologic hyperglucagonemia on splanchnic glucose output, glucagon was infused in a dose of 3 ng/kg per min to healthy subjects in the basal state and after splanchnic glucose output had been inhibited by an infusion of glucose (2 mg/kg per min). In the basal state, infusion of glucagon causing a 309 +/- 25 pg/ml rise in plasma concentration was accompanied by a rapid increase in splanchnic glucose output to values two to three times basal by 7-15 min. The rise in… CONTINUE READING

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