Influence of phasic and tonic dopamine release on receptor activation.

  title={Influence of phasic and tonic dopamine release on receptor activation.},
  author={Jakob Kisbye Dreyer and Kjartan Frisch Herrik and Rune W. Berg and J\orn Hounsgaard},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 42},
Tonic and phasic dopamine release is implicated in learning, motivation, and motor functions. However, the relationship between spike patterns in dopaminergic neurons, the extracellular concentration of dopamine, and activation of dopamine receptors remains unresolved. In the present study, we develop a computational model of dopamine signaling that give insight into the relationship between the dynamics of release and occupancy of D(1) and D(2) receptors. The model is derived from first… CONTINUE READING
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