Influence of pharmacological PPARalpha activators on carnitine homeostasis in proliferating and non-proliferating species.

@article{Ringseis2009InfluenceOP,
  title={Influence of pharmacological PPARalpha activators on carnitine homeostasis in proliferating and non-proliferating species.},
  author={Robert Ringseis and Klaus Eder},
  journal={Pharmacological research},
  year={2009},
  volume={60 3},
  pages={
          179-84
        }
}
Former studies in rats demonstrated that starvation or treatment with the hypolipidemic drug clofibrate causes a marked increase in the concentration of carnitine in the liver. The molecular mechanisms underlying these phenomena in rats, however, have been largely unknown. Since both, fasting and clofibrate treatment lead to an activation of peroxisome proliferator-activated receptor alpha (PPARalpha), a ligand-activated transcription factor that acts as an important regulator of lipid… CONTINUE READING

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