Influence of peroxisome proliferator-activated receptor gamma activation by its endogenous ligand 15-deoxy Delta12,14 prostaglandin J2 on nitric oxide production in term placental tissues from diabetic women.

@article{Jawerbaum2004InfluenceOP,
  title={Influence of peroxisome proliferator-activated receptor gamma activation by its endogenous ligand 15-deoxy Delta12,14 prostaglandin J2 on nitric oxide production in term placental tissues from diabetic women.},
  author={Alicia Jawerbaum and Evangelina Capobianco and Carolina Pustovrh and Ver{\'o}nica White and Mario Baier and Samuel Salzberg and Marzia Pesaresi and Elida Gonz{\'a}lez},
  journal={Molecular human reproduction},
  year={2004},
  volume={10 9},
  pages={671-6}
}
Diabetes induces alterations which condition placental remodelling. The levels of nitric oxide (NO) (a modulator of placental invasiveness, differentiation and proliferation) were higher in term placental explants from diabetic patients when compared to controls. Peroxisome proliferator-activated receptor gamma (PPARgamma) activation by its endogenous ligand 15-deoxy Delta(12,14)prostaglandin J(2) (15dPGJ(2)), is a differentiating factor of adipocytes and other cell types, such as trophoblasts… CONTINUE READING

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