Influence of periodontal disease, Porphyromonas gingivalis and cigarette smoking on systemic anti-citrullinated peptide antibody titres.

@article{Lappin2013InfluenceOP,
  title={Influence of periodontal disease, Porphyromonas gingivalis and cigarette smoking on systemic anti-citrullinated peptide antibody titres.},
  author={David Francis Lappin and Danae Anastasia Apatzidou and Anne-Marie Quirke and Jessica Oliver-Bell and J. Butcher and Denis F. Kinane and Marcello Pasquale Riggio and Patrick J W Venables and Iain B. Mcinnes and Shauna Culshaw},
  journal={Journal of clinical periodontology},
  year={2013},
  volume={40 10},
  pages={907-15}
}
BACKGROUND Anti-citrullinated protein antibody (ACPA) responses may precede clinical onset of rheumatoid arthritis. Porphyromonas gingivalis peptidylarginine deiminase can citrullinate proteins possibly inducing autoimmunity in susceptible individuals. AIM To determine whether periodontitis, carriage of P. gingivalis, smoking and periodontal therapy influence ACPA titres. METHODS Serum and plaque samples were collected from 39 periodontitis patients before and after non-surgical periodontal… CONTINUE READING
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