Influence of penicillamine and various analogs on matrix-induced bone formation in rats.

Abstract

D-penicillamine and a variety of analogs have been tested for their ability to interfere with the various stages of bone development using a model for endochondral bone formation. At the highest dose tested (40 mg/rat/day), D-penicillamine inhibited mineralization, D-2-Amino-3-methyl-3-[(2-acetamidoethyl)dithio]butanoic acid (II), at a relatively low dose (10 mg/day), decreased the amount of insoluble collagen in skin, mesenchymal cell proliferation on Day 3, and inhibited bone formation on Day 14. Several other compounds tested, sodium 4-[(D-1, 1-dimethyl-2-amino-2-carboxyethyl)-dithio]butanesulfinate (IV), 2-acetamidoethyl-2-acetamidoethanethiolsulfonate (V), and sodium 4-mercaptobutanesulfinate trihydrate (VI), also inhibited osteogenesis on Day 14.

Cite this paper

@article{Weiss1984InfluenceOP, title={Influence of penicillamine and various analogs on matrix-induced bone formation in rats.}, author={Robert E. Weiss and Lyndsay Field and A H Gorn and Carlumandarlo Williams and Shlomo Dux and Rajeswari Ravichandran and August A. Gallo and V Eswarakrishnan and Marcel E. Nimni}, journal={Biochemical medicine}, year={1984}, volume={32 3}, pages={331-6} }