Influence of patient-related variables on clozapine plasma levels.

  title={Influence of patient-related variables on clozapine plasma levels.},
  author={Christian Haring and Walter Wolfgang Fleischhacker and Prof. Dr. G. Schett and Christian Humpel and Christian Barnas and Alois Saria},
  journal={The American journal of psychiatry},
  volume={147 11},
The authors investigated the clozapine plasma levels of 148 psychiatric inpatients. Multiple regression analysis revealed a linear relationship between dose of clozapine and plasma concentrations. The analysis showed a significant influence of dose, sex, smoking, weight, and age on the plasma concentrations of clozapine under clinical conditions. These results remained significant when clozapine doses below 150 mg/day and above 500 mg/day were excluded from the analysis. 

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