Influence of parenteral administration routes and additional factors on vaccine safety and immunogenicity: a review of recent literature

@article{Herzog2014InfluenceOP,
  title={Influence of parenteral administration routes and additional factors on vaccine safety and immunogenicity: a review of recent literature},
  author={Christian Herzog},
  journal={Expert Review of Vaccines},
  year={2014},
  volume={13},
  pages={399 - 415}
}
  • C. Herzog
  • Published 13 February 2014
  • Medicine
  • Expert Review of Vaccines
Vaccines have to be administered via an appropriate route, i.e. a route, which is optimal regarding safety, immunogenicity and practicability. In addition, there are factors, such as body site, needle length, injection technique, depth of injection, type of antigen, vaccine formulation, adjuvants, age, sex, race/ethnicity, body mass, and pre-existing immunity, which can have an impact on the reactogenicity and tolerability and/or on the immunogenicity of a given vaccine. For parenteral vaccine… 

Topics from this paper

Safety assessment of adjuvanted vaccines: Methodological considerations
Adjuvants mainly interact with the innate immune response and are used to enhance the quantity and quality of the downstream adaptive immune response to vaccine antigens. Establishing the safety of a
Skin receptors agonists as novel adjuvants for Meningococcal glycoconjugate vaccines: the impact of antigen-agonist conjugation and evaluation of intradermal vaccine delivery as an alternative to the intramuscular route
TLDR
The in vivo evaluation of novel vaccines suitable for intradermal delivery and able to induce earlier onset of immune response as well as more potent and longer lasting immune responses in comparison to conventional vaccines provided encouraging results with respect to quantity, quality and functionality of the induced immune responses.
Comparison of intramuscular and subcutaneous administration of a herpes zoster live-attenuated vaccine in adults aged ≥50 years: a randomised non-inferiority clinical trial.
TLDR
In adults aged ≥50 years, IM administration of Zostavax elicited similar immune responses to SC administration and was well tolerated, with fewer injection-site reactions than with SC administration.
Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?
TLDR
In this review the different strategies for the delivery of prophylactic and therapeutic subunit vaccines along with the impact of these on the immune responses generated are discussed.
Virus-like particle vaccines: immunology and formulation for clinical translation
TLDR
The purpose of this review is to outline the diversity of VLP vaccines, VLP-specific immune responses, and to explore how modern formulation and delivery techniques can enhance the clinical relevance and overall success of V LP vaccines.
Immunogenicity and safety of intramuscular versus subcutaneous administration of a combined measles, mumps, rubella, and varicella vaccine to children 12 to 18 months of age
TLDR
Two doses of the MMRV vaccine were highly immunogenic and well tolerated when administered either SC or IM, and all vaccine antigens 6 weeks after the second dose of MMRV were > 99% in both the IM and SC groups.
Precision immunization: a new trend in human vaccination
TLDR
This review addresses the concept and framework of precision immunization, summarizes recent and representative clinical trials of among specific populations, mentions important factors to be addressed in customizing vaccinations, and provides suggestions on the establishment of precision Immunization with the goal of maximizing the effectiveness of vaccines in general.
...
1
2
3
4
...

References

SHOWING 1-10 OF 148 REFERENCES
[Are there differences in immunogenicity and safety of vaccines according to the injection method?].
TLDR
Immunogenicity and safety results are in favor of intramuscular vaccination, and the appropriate needle length must to be adapted according to the morphological aspects (subcutaneous tissue and muscle thickness).
Current evidence on intradermal influenza vaccines administered by Soluvia™ licensed micro injection system
TLDR
Licensed intradermal influenza vaccines can be considered a valid alternative to standard intramuscular vaccination offering significant advantages in low-responder populations and helping to increase influenza vaccination coverage rates especially in people with fear of needles or high apprehension associated with annual vaccination.
Intradermal delivery for vaccine dose sparing: overview of current issues.
TLDR
A number of clinical and technical research as well as operational challenges exist, including establishing the optimal doses for different vaccines, reformulating to adjust antigen concentration or add preservatives, matching vaccine vial volume to session size, and developing ID delivery devices suitable for the varying scenarios of use of different vaccines.
Immunogenicity and safety of a new inactivated hepatitis A vaccine: a clinical trial with comparison of administration route.
TLDR
This inactivated hepatitis A vaccine appeared to be highly immunogenic after one single dose and one booster 6 months later and no statistically significant differences were observed in the three paired comparisons.
Evidence based route of administration of vaccines
TLDR
Application of evidence-based medicine to the route of administration of vaccines demonstrates that vaccines should be given by intramuscular injection in preference to subcutaneous injection as the intramUScular route is associated with better immune response and a lower rate of injection site reaction.
Vaccine injection technique and reactogenicity--evidence for practice.
Virosomal hepatitis a vaccine: comparing intradermal and subcutaneous with intramuscular administration.
TLDR
The aluminum-free virosomal HAV vaccine Epaxal is highly immunogenic and well tolerated when administered either via i.d., s.c., or i.m.m, and may confer significant cost savings over the conventional i.c. and s.d. route.
...
1
2
3
4
5
...