Influence of pH on calcium influx during hypoxia in rat cortical brain slices.

Abstract

BACKGROUND AND PURPOSE Acidity of brain intracellular and extracellular fluids appears to increase brain injury from stroke, but low extracellular pH decreases the activity of N-methyl-D-aspartate receptor ion channels and decreases calcium influx into isolated neurons. To further investigate the role of acid-base balance in hypoxic brain injury, we studied… (More)

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