Influence of oxidized purine processing on strand directionality of mismatch repair.

Abstract

Replicative DNA polymerases are high fidelity enzymes that misincorporate nucleotides into nascent DNA with a frequency lower than [1/10(5)], and this precision is improved to about [1/10(7)] by their proofreading activity. Because this fidelity is insufficient to replicate most genomes without error, nature evolved postreplicative mismatch repair (MMR… (More)
DOI: 10.1074/jbc.M114.629907

Cite this paper

@article{Repmann2015InfluenceOO, title={Influence of oxidized purine processing on strand directionality of mismatch repair.}, author={Simone Repmann and Maite Olivera-Harris and Josef Jiricny}, journal={The Journal of biological chemistry}, year={2015}, volume={290 16}, pages={9986-99} }