Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression.

@article{Bernardi1989InfluenceOO,
  title={Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression.},
  author={Mara Bernardi and Anna Valeria Vergoni and Maurizio Sandrini and Simonetta Tagliavini and Alfio Bertolini},
  journal={Physiology & behavior},
  year={1989},
  volume={45 5},
  pages={1067-8}
}
In the tail suspension test (an animal model of depression) the duration of immobility during the 6 min of observation was 56.84 +/- 6.54 sec in sham-ovariectomized mice and 113.11 +/- 7.86 sec 30-32 days after ovariectomy. Estradiol (10, 100 or 1,000 micrograms/kg) and progesterone (50, 1,000 or 10,000 micrograms/kg), subcutaneously injected daily 4 times before the test, restored the duration of immobility in ovariectomized mice to normal, while having no effect on sham-operated animals. On… CONTINUE READING