Influence of ototoxic drugs on acetylcholine-induced depression of the cochlear N1 potential.

@article{Daigneault1970InfluenceOO,
  title={Influence of ototoxic drugs on acetylcholine-induced depression of the cochlear N1 potential.},
  author={Ernest A. Daigneault and John R. Pruett and Rodney D. Brown},
  journal={Toxicology and applied pharmacology},
  year={1970},
  volume={17 1},
  pages={
          223-30
        }
}
  • Ernest A. Daigneault, John R. Pruett, Rodney D. Brown
  • Published in
    Toxicology and applied…
    1970
  • Medicine
  • Abstract Cats were prepared to record from the cochlear round window. The cochlear potential (N 1 ) is depressed by 15–30 μg of acetylcholine administered intra-arterially before and after section of the eighth cranial nerve. The acute administration of 1.0 mg of quinine, streptomycin, kanamycin, and neomycin blocked the peripheral effectiveness of acetylcholine for durations of 20, 20, 60, and more than 120 min, respectively. The effects of dihydrostreptomycin were similar but not… CONTINUE READING

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