Influence of osmolytes and denaturants on the structure and enzyme activity of alpha-chymotrypsin.

@article{Attri2010InfluenceOO,
  title={Influence of osmolytes and denaturants on the structure and enzyme activity of alpha-chymotrypsin.},
  author={Pankaj Sharma Attri and Pannuru Venkatesu and Ming-Jer Lee},
  journal={The journal of physical chemistry. B},
  year={2010},
  volume={114 3},
  pages={1471-8}
}
Enzymes are very sensitive and highly complex systems, exhibiting a substantial degree of structural variability in their folded state. In the presence of cosolvents, the fluctuations among vast numbers of folded and unfolded conformations occur via many different pathways, and alternatively, enzymes can be stabilized or destabilized. To understand the contribution of osmolytes and denaturants on the stabilization, related to the associated structural changes and enzyme activity of alpha… CONTINUE READING

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