Influence of orally and rectally administered propionate on cholesterol and glucose metabolism in obese rats

@article{Berggren1996InfluenceOO,
  title={Influence of orally and rectally administered propionate on cholesterol and glucose metabolism in obese rats},
  author={Anna Berggren and E M Nyman and Ingmar Lundquist and Inger M. E. Bj{\"o}rck},
  journal={British Journal of Nutrition},
  year={1996},
  volume={76},
  pages={287 - 294}
}
It has increasingly been suggested that the short-chain fatty acids (SCFA) acetic, propionic and butyric acids, derived from colonic fermentation of dietary fibre and other indigestible carbohydrates, exert different physiological effects. Formation of propionic acid is discussed in terms of beneficial effects on glucose and cholesterol metabolism. The aim of the present study was to evaluate possible metabolic effects of propionic acid and to differentiate between effects mediated in the upper… 

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References

SHOWING 1-10 OF 44 REFERENCES

Effects of dietary propionate on hepatic glucose production, whole-body glucose utilization, carbohydrate and lipid metabolism in normal rats

The results show that dietary propionate chronically ingested by normal rats could decrease fasting glycaemia, but from the findings, no effect on hepatic glucose production and whole-body glucose utilization could be clearly demonstrated.

Effect of propionate on in vivo carbohydrate metabolism in streptozocin-induced diabetic rats.

Effects of dietary propionate on carbohydrate and lipid metabolism in healthy volunteers.

The results suggest that the improvement in glucose tolerance and insulin sensitivity and the known beneficial effect of dietary fiber on HDL metabolism may in part be mediated through effects of propionate on hepatic carbohydrate metabolism.

Comparison between physiological effects of konjac-glucomannan and propionate in baboons fed "Western" diets.

Compared the effects of a soluble dietary fiber concentrate, konjac-glucomannan (K-GM), and of propionate on plasma fibrinogen, serum and liver lipid, glucose tolerance, insulin response and liver glycogen in baboons with a "Western" diet and a crossover, randomized order.

Hypocholesterolaemic effects of dietary propionate: studies in whole animals and perfused rat liver.

It appears that a redistribution of cholesterol from the plasma to the liver, rather than inhibition of hepatic and intestinal cholesterol synthesis, is responsible for the hypocholesterolaemic effects of dietary propionate.

Changes in pig serum lipids, nutrient digestibility and sterol excretion during cecal infusion of propionate.

The results suggest that propionate absorption does not result in decreased serum lipids and is not responsible for the serum lipid-lowering effects of water-soluble fibers.

Interaction between colonic acetate and propionate in humans.

Results are consistent with the hypothesis that colonic propionate is a gluconeogenic substrate in humans and inhibits the utilization of acetate for cholesterol synthesis.

High propionic acid fermentations and mineral accumulation in the cecum of rats adapted to different levels of inulin.

In conclusion, inulin seems very effective in promoting propionic fermentation and in enhancing the calcium content of the large intestine, however, high levels of inulin (greater than 10%) may affect growth in rats and lead to acidic cecal fermentation.

INFLUENCE OF PROPIONIC ACID ON THE CHOLESTEROL METABOLISM OF PIGS FED HYPERCHOLESTEROLEMIC DIETS

Sixty-four crossbred pigs averaging 24 kg liveweight were used to study the effects of dietary propionic acid (PA) on plasma and tissue cholesterol concentrations of pigs fed hypercholesterolemic

Propionate Inhibits Hepatocyte Lipid Synthesis

It is suggested that propionate may inhibit cholesterol and fatty acid biosynthesis in vivo and may mediate in part the hypolipidemic effects of soluble dietary fiber.