Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man.

@article{Greenhaff1993InfluenceOO,
  title={Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man.},
  author={Paul L. Greenhaff and Anna Casey and A. H. Short and R. C. Harris and K Soderlund and Eric Hultman},
  journal={Clinical science},
  year={1993},
  volume={84 5},
  pages={
          565-71
        }
}
1. The present experiment was undertaken to investigate the influence of oral creatine supplementation, shown previously to increase the total creatine content of human skeletal muscle (Harris RC, Soderlund K, Hultman E. Clin Sci 1992; 83: 367-74), on skeletal muscle isokinetic torque and the accumulation of plasma ammonia and blood lactate during five bouts of maximal exercise. 2. Twelve subjects undertook five bouts of 30 maximal voluntary isokinetic contractions, interspersed with 1 min… 

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References

SHOWING 1-10 OF 16 REFERENCES

Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation.

Competition with 5g of creatine monohydrate, four or six times a day for 2 or more days resulted in a significant increase in the total creatine content of the quadriceps femoris muscle measured in 17 subjects, and in some the increase was as much as 50%.

Creatine phosphate in fiber types of skeletal muscle before and after exhaustive exercise.

It is concluded that basal CP content is higher in FT fibers than in ST fibers after a 60-s recovery period after maximal short-term exercise, consistent with the different metabolic profiles of FT and ST fibers.

Muscle ATP turnover rate during isometric contraction in humans.

It is concluded that a major determinant of the ATP turnover rate is the muscle fiber composition, which is probably explained by a higher turnover rate in fast-twitch fibers; fatigue is more closely related to a low phosphocreatine content than to a high lactate content; and the increase in prephosphofructokinase intermediates is important for stimulating glycolysis during contraction.

Anaerobic energy release in skeletal muscle during electrical stimulation in men.

The quadriceps femoris muscles of seven men were electrically stimulated under extended anaerobic conditions to quantitate an aerobic energy release and the contribution of the glycolytic system to total ATP production andglycolysis produced approximately 195 mmol ATP/kg dry muscle during the initial 48 contractions and only approximately 15 mmol ATP-1 X s-1 during the final 16 contractions.

Human muscle metabolism during sprint running.

The study demonstrated that a significant reduction in ATP occurs during maximal dynamic exercise in humans and the marked metabolic changes caused by the treadmill sprint makes it a valuable test for examining the factors that limit performance and the etiology of fatigue during brief maximal exercise.

Energy metabolism in type I and type II human muscle fibres during short term electrical stimulation at different frequencies.

It is hypothesized that the decline in whole muscle force observed during electrical stimulation may be a consequence of the rapid loss of PCr stores in type II fibres.

Breakdown and resynthesis of phosphorylcreatine and adenosine triphosphate in connection with muscular work in man.

It has been demonstrated that a reverse relationship exists between the work load and the PC concentration in the muscle during work, and at very high work loads thePC concentration decreases rapidly down to zero and the contractive capaci...

Methods of Enzymatic Analysis