Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents.

@article{Katchman2002InfluenceOO,
  title={Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents.},
  author={Alexander N Katchman and Kelly A McGroary and Michael J. Kilborn and Craig A Kornick and Paolo L Manfredi and Raymond L Woosley and Steven N Ebert},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={303 2},
  pages={688-94}
}
We have evaluated the ability of various opioid agonists, including methadone, L-alpha-acetylmethadol (LAAM), fentanyl, meperidine, codeine, morphine, and buprenorphine, to block the cardiac human ether-a-go-go-related gene (HERG) K(+) current (I(HERG)) in human cells stably transfected with the HERG potassium channel gene. Our results show that LAAM, methadone, fentanyl, and buprenorphine were effective inhibitors of I(HERG), with IC(50) values in the 1 to 10 microM range. The other drugs… CONTINUE READING
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