Influence of olanzapine on cognitive functions and catalepsy in rats after single and chronic administration.

@article{Nowakowska1999InfluenceOO,
  title={Influence of olanzapine on cognitive functions and catalepsy in rats after single and chronic administration.},
  author={Elżbieta Nowakowska and Alfons Chodera and Krzysztof Kus},
  journal={Polish journal of pharmacology},
  year={1999},
  volume={51 4},
  pages={295-300}
}
The aim of our investigations was to supplement the scarce information about behavioral effects of olanzapine and especially to find out if the effects change during prolonged treatment. It was established that at a dose of 0.5 mg/kg, which did not evoke sedation, olanzapine had distinct anxiolytic effects, both after acute and chronic treatment. Olanzapine improved memory in the maze test (food finding time), but only in chronic experiments after a lag of 14 days. Olanzapine at the dose of 0.5… CONTINUE READING

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