Influence of oestradiol on alpha2-adrenoceptor binding sites on intact platelets of young male volunteers

Abstract

The specific binding (Bmax) of (3H-methyl)yohimbine to alpha2-adrenoceptor binding sites on intact platelets was increased by 43% in 6 out of 7 young male volunteers 4 days after a single i.m. injection of 10 mg sustained release oestradiol, and it had returned to the starting value 4 weeks after drug administration. Mean plasma oestradiol was 331 pg/ml on Day 4 and it was within the pre-treatment control range of 19 pg/ml 4 weeks after the injection. A close correlation between the post-injection plasma oestradiol concentration and the increase in alpha2-adrenoceptor binding sites on intact platelets was not found.

DOI: 10.1007/BF00544558

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Cite this paper

@article{Reimann1987InfluenceOO, title={Influence of oestradiol on alpha2-adrenoceptor binding sites on intact platelets of young male volunteers}, author={Ingrid W. Reimann and C. Britzelmeier and Paul S. Haber and Hartmut A. Wollmann and K. H. Antonin and Peter R. Bieck}, journal={European Journal of Clinical Pharmacology}, year={1987}, volume={33}, pages={147-150} }