Influence of non-P region domains on selectivity filter properties in voltage-gated K+ channels.

@article{Immke1998InfluenceON,
  title={Influence of non-P region domains on selectivity filter properties in voltage-gated K+ channels.},
  author={David Immke and L{\'a}szl{\'o} Kiss and Joseph J. Loturco and Stephen J. Korn},
  journal={Receptors & channels},
  year={1998},
  volume={6 3},
  pages={179-88}
}
The selectivity filter in voltage-gated K+ channels is formed at the interface of the pore loops (S5-S6 loop) from four channel subunits. Whereas most K+ channels are essentially impermeable to Na+, the Kv2.1 K+ channel conducts Na+ relatively well in the absence of K+ and selects for K+ over Na+ at least partially by an affinity-based competition mechanism. To examine whether the ability of Kv2.1 to conduct Na+ reflected unique properties of either its S5-S6 loop or channel domains that held… CONTINUE READING