Influence of nitric oxide modulators on cholinergically stimulated hormone release from mouse islets.

@article{Aringkesson1999InfluenceON,
  title={Influence of nitric oxide modulators on cholinergically stimulated hormone release from mouse islets.},
  author={B Aringkesson and Ingmar Lundquist},
  journal={The Journal of physiology},
  year={1999},
  volume={515 ( Pt 2)},
  pages={463-73}
}
1. We have investigated, with a combined in vitro and in vivo approach, the influence on insulin and glucagon release stimulated by the cholinergic, muscarinic agonist carbachol of different NO modulators, i.e. the nitric oxide synthase (NOS) inhibitors NG-nitro-L-arginine methyl ester (L-NAME), NG-monomethyl-L-arginine (L-NMMA) and 7-nitroindazole as well as the intracellular NO donor hydroxylamine. 2. At basal glucose (7 mM) carbachol dose-dependently stimulated insulin release from isolated… CONTINUE READING
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