Influence of new estrogens on liver transport function in rats.

Ethinylestradiol (EE), administered to male Wistar rats for 5 or 14 days, decreased bile flow and biliary excretion of ICG in bile fistula rats in dependence on dose. The bile acid excretion rate was not constantly influenced. EE pretreatment of rats also diminished the in vitro accumulation of eosine in liver slices. The new estrogens STS 651 and STS 661… CONTINUE READING