Influence of mucosal adjuvants on antigen passage and CD4+ T cell activation during the primary response to airborne allergen.

@article{Wikstrom2006InfluenceOM,
  title={Influence of mucosal adjuvants on antigen passage and CD4+ T cell activation during the primary response to airborne allergen.},
  author={Matthew E. Wikstrom and Eva Batanero and M Elizabeth Smith and Jennifer A. Thomas and Christophe von Garnier and Patrick G. Holt and Philip A. Stumbles},
  journal={Journal of immunology},
  year={2006},
  volume={177 2},
  pages={913-24}
}
Ag delivery via the nasal route typically induces tolerance or fails to polarize CD4+ T cell responses unless an adjuvant is provided. To better understand this process, we assessed the effects of two mucosal adjuvants, Escherichia coli LPS and cholera toxin (CT), on Ag passage and T cell activation in the draining lymph nodes (DLN) of BALB/c mice following per nasal administration of the model protein allergen, OVA. We found a range of cell types acquired small amounts of fluorescent OVA in… CONTINUE READING