Influence of micropattern width on differentiation of human mesenchymal stem cells to vascular smooth muscle cells.

@article{Nakamoto2014InfluenceOM,
  title={Influence of micropattern width on differentiation of human mesenchymal stem cells to vascular smooth muscle cells.},
  author={Tomoko Nakamoto and Xinlong Wang and Naoki Kawazoe and Guoping Chen},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2014},
  volume={122},
  pages={316-323}
}
In recent years, various approaches have been taken to generate functional muscle tissue by tissue engineering. However, in vitro methods to generate smooth muscle with physiologically aligned structure remains limited. In order to mimic the in vivo highly organized structure of smooth muscle cells, we used micropatterning technology for engineering parallel aligned cells. In this study, a gradient micropattern of different width of cell-adhesive polystyrene stripes (5, 10, 20, 40, 60, 80, 100… CONTINUE READING